Real Research Pharmacokinetics research on LifeCube

LifeCube is innovative device which allows you to expose 3D cell structures to more pharmacologically relevant drug dosing regimens.

The device recreates the drug concentration profiles recorded in the clinic using programmable pairs of pumps.  Not only can the relevant PK profiles be applied to 3D cells to mimic typical injection or infusion strategies, but multiple dosing schemes over several weeks can be simulated and compared.

This platform will help define the most effective chemotherapy strategies for specific cell types based on choice of drug concentration and administration frequency.

APPLICATION

• Simulation of drug pharmacokinetics and pharmacodynamics for  3D tumor cell structures

Step 1

You send us your chosen cell line and drug.

Step 2

3D cell culture in LifeCube: The programmable LifeCube pumping system can mimic drug pharmacokinetics, allowing evaluation of efficacy with different dosing regimens.

Step 3

You will get the results of our work: a record of cellular response determined by microscopic observation and cell viability data. We can carry out other specific assays at your request (e.g. staining, DNA quantitation), or optimise dosing frequency and concentration for maximum effect.

Why us?

• Cell culture on our patented LIFE TECHNOLOGY

• Innovative LifeCube platform.

• Expertise in setting up and performing 3D cell cultures under drug    flow conditions.