Inspired by Nature.
Empowered by Technology.
Committed to Life.
Advancing Human-Relevant Systems to Reduce Reliance on Animal Models
Integrated • Predictive • Translational
Accelerating Smarter, More Human-Relevant Medicine
Dynamic Microenvironment & Fluidic Culture Systems
Human biology is dynamic. Preclinical models should be too.
Biologically relevant models require dynamic microenvironments, controlled flow, and physiologically meaningful exposure conditions.
At NAMina Bio, we integrate advanced fluidic culture technologies to recreate perfusion, shear stress, and microenvironmental gradients in vitro, enabling more physiologically relevant models for translational research, therapeutic testing, and systems-level biology.
Why Dynamic Culture Matters
Most preclinical systems fail not because they lack complexity, but because they lack dynamics.
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Nutrient and oxygen gradients are not preserved
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Drug exposure is artificially static
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Mechanical forces and shear are absent
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Cellular adaptation is not captured over time
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Lack of cross-modulation between tissues, in particular when they are not physically in contact
As a result, critical biological signals are missed, leading to poor translational predictivity and failure to capture clinically relevant resistance mechanisms.
The NAMina Approach
NAMina proposes a workflow that integrates different technologies to design a dynamic setup, aligning biological models with their intended context of use.
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2D or 3D barriers models in liquid-liquid (LLI) o air-liquid (ALI) interface
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2D or 3D target organs, based on cell cultures, organoids and biopsies
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Multi-organ set-up, in patho-physiological conditions, filling the gap with the need of tissues crosstalk
This workflow is designed around technologies that comply with standard protocols, enabling a smooth transition from static to more complex scenarios.
What This Enables
Advanced Biological Modeling
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Constant or variable dynamic stimulation to recapitulate the blood action in human circulation
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More relevant barriers models, with different environmental
(e.g., type of medium, flow rate) conditions at the interface
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Interaction between tissues, mediated by liquid exchange, even with circulating material (e.g., metastasis)
Translational Drug Testing
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Chronic or acute drug administration and its bioavailability
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Drug delivery systems: permeability and interaction with a target tissue
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Drug action and its side effects in a pathological scenario
Mechanistic Insights
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Tissue-tissue flow mediated crosstalk
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Dynamic phenotype adaptation
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Simulation of immune response and inflammatory events
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Evaluation of dynamic drug treatment efficacy
(e.g., tumour resistance to chemotherapy)
Types of Dynamic Models Available
IVTech provides fluidic culture technologies that enable dynamic, physiologically relevant in vitro systems.
Within the NAMina platform, these capabilities are integrated into broader translational workflows to support time-resolved, context-of-use driven biological modeling.
NAMina also acts as a channel partner for IVTech, enabling access to these technologies as part of integrated experimental programs or standalone platform deployment, including support for system selection, setup, and experimental design.
NAMina enables multiple classes of dynamic models, each configured based on biological context and translational objective.
Perfused Tumor & Organoid Systems
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Embedded and floating organoids
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Acute and chronic drug administration
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Long-term adaptation and resistance studies
Barrier & Interface Models
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Transwell-like architecture with removable membrane
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Air-Liquid Interface (ALI)
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Liquid-liquid Interface (LLI)
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Real-time monitoring through standard protocols (e.g., imaging, liquid sampling, TEER evaluation)
Designed for permeability, transport, and interface: biology studies.
Applications:
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Lung models
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Gut permeability
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Blood-brain barrier
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Drug absorption
Multi-Organ Systems
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Modular “plug-and-play” architecture
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Interconnected tissues in series
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Simulates systemic drug response
Enables:
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PK/PD-like modeling
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Cross-organ toxicity
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Tumor–organ interaction
Integration with NAMina Platform
Dynamic culture systems are orchestrated within the NAMina platform to integrate:
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Mature tumoroids (LifeGel platform)
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3D bioprinting systems
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Multi-omics profiling (NGS + analytics)
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Functional sensing platforms
Creating a multi-scale, time-resolved experimental framework designed to generate decision-ready biological insights.
Why This Matters
By integrating dynamic systems, NAMina enables:
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Transition from static → time-evolving biology
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Detection of effects otherwise lost in static systems
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Improved prediction of clinical outcomes
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Reduction of false negatives in early screening
NAMina enables perfused tumor systems, barrier models, and multi-organ dynamic workflows
Translational Dynamic Microenvironment Programs
Designed as modular, context-of-use driven programs:
Module 1 — Perfused Tumor Systems & Resistance Modeling
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Perfused tumoroid systems under controlled flow
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Time-dependent resistance evolution and adaptation
Designed to reveal clinically relevant resistance mechanisms emerging under dynamic conditions.
Module 2 — Barrier Function & Drug Penetration Programs
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Quantitative drug permeability and transport analysis
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Interface biology under ALI/LLI conditions
Enables accurate assessment of drug absorption, penetration, and barrier function.
Module 3 — Systemic Response & Multi-Organ Modeling
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Systemic drug response and distribution modeling
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Cross-tissue signaling and organ interaction
Supports system-level understanding of drug effects across interconnected tissues.
Start a Pilot Program
Tell us about your biological question, therapeutic focus, or experimental goal.
Our team will design a tailored dynamic microenvironment program aligned with your context of use.